Using lineage tracing, we find that tissue-resident red pulp macrophages (RPM), initially depleted by BCG exposure, are restored from both tissue-trained, self-renewing macrophages and from bone ...

Among the immune cells of the innate and adaptive immune response involved in the pathogenesis of obesity-related diseases, macrophages play a crucial role in the inflammation associated with CKD. In ...

Macrophages, key modulators of immune responses, play a dual role in both promoting and resolving inflammation. Exosomes, small extracellular vesicles released by various cells, carry bioactive ...

Inflammation is triggered by the immune system and is part of the body's natural response to injuries or disease. However, ...

Researchers from the Epigenetics and Immune Disease Laboratory at the Josep Carreras Leukaemia Research Institute in ...

The underlying regulatory mechanisms of metabolic switching are assessed by both in vitro and in vivo studies. Conclusions Selectively modulating the ‘context’ of glycolytic macrophages in HCC tumours ...

Resident Evil movies are bad, or that’s probably what you’ve heard over the years. But look, some of them have their merits, and aren’t the huge Hollywood disaster you may think it is. The best of ...

The study's findings are crucial in the rapidly emerging field of developing disease-modifying therapies that target microglia.