The general strategy for therapeutically targeting proteases is to identify a specific inhibitor — generally a small molecule — that blocks the active site. As discussed below, discovery ...

Among the identified putative protease inhibitors, a series of broad-acting compounds targeting the coronavirus 3CL protease and papain-like protease were validated through biochemical and live virus ...

This may be explained by methodological factors including cell isolation techniques, cell types and ambient pH. In this study, we tested whether the use of protease XIV (PXIV) may abrogate inhibition ...

and proximity-ligation based assays for active proteases (using a combination of peptides that bind only to the active form of proteases and specific antibody) and protease–inhibitor complexes. Most ...

This study presents a valuable finding on the role of secretory leukocyte protease inhibitors (SLPI) in developing Lyme disease in mice infected with Borrelia burgdorferi. The evidence supporting the ...

Our lab has created prototype mesotrypsin inhibitors with improved affinity by using site-directed mutagenesis, biochemical assays and X-ray crystallography to define features of mesotrypsin ...