Just when immunologists thought the basic principles for the somatic diversification of antigen receptors for B and T cells had ... or into plasma cells that secrete antibodies (the soluble ...

Long-lived plasma cells, which produce autoantibodies in diseases such as systemic lupus erythematosus (SLE), are an as yet unexplored therapeutic target in such antibody-mediated disorders.

Clonal plasma cells in the bone marrow secrete free light chains into circulation. These light chains are part of immunoglobulins, also called antibodies. But in this disease, light chains misfold ...