This feature has been exploited for the development of bioorthogonal reactions, including the Staudinger ligation of azides with functionalized phosphines and the [3+2] cycloaddition of azides ...

Figure 1 PD-1 functions and PD-L1 expression are mediated by SHP2, PTPN2, PAG, ITK, GSK-3, VRK2, and CDK4/6 signaling. SHP2 is recruited downstream of PD-1 ligation and mediates a number of subsequent ...

T lymphocytes are important mediators of adoptive immunity but the mechanism of T cell receptor (TCR) triggering remains uncertain. The interspatial distance between engaged T cells and ...

Recent studies have highlighted the functional capacity of neutrophils as powerful mediators of tissue inflammation. Granule-packaged proteases and reactive oxygen intermediates, which are ...

Collagen is the primary building block of your body's skin, muscles, bones and more. But it's hard to keep the levels in check because as you age, your body's collagen levels naturally decline.