Drugs targeting amyloid plaques have failed to show efficacy in clinical trials. A new approach is needed to tackle AD ...

Exercise may positively influence the interactions between brain cells in the hippocampus, a brain region involved in ...

The possibility that Alzheimer’s disease diagnosis is associated with viruses, bacteria, fungi, and parasites has been ...

Headline after headline has been written about a 2024 study, published in the scientific journal Biomolecules, which suggests ...

Pyramidal neuron. Neurofibrillary tangles. Light micrograph of a human cerebral cortex showing neurofibrillary tangles in several pyramidal neurons. Neurofibrillary tangles (NFTs) are a characteristic ...

LY3372689 was designed to slow the accumulation of hyper-phosphorylated, insoluble tau aggregates in the central nervous system, which clump together to form neurofibrillary 'tangles', one of the ...

In conditions like Alzheimer's and frontotemporal dementia, tau proteins become damaged, detach, and form toxic neurofibrillary tangles that harm neurons. This damage disrupts communication in the ...

In PSP, there is gross midbrain atrophy and neuronal loss, gliosis and abundant neurofibrillary tangles and neuropil threads in many brain regions. There is a uniform presence of tau-positive ...

“This approach could help bolster the brain’s innate immune response while avoiding the formation of neurofibrillary tangles that exacerbate the disease,” he continued. “By understanding ...