So et al. present an optimized protocol for single-nuclei RNA sequencing of adipose tissue in mice, ensuring better RNA quality and nuclei integrity. The authors use this protocol to explore the ...

Olfactory receptors, classified as G-protein coupled receptors (GPCRs), have been a subject of scientific inquiry since the early 1950s. Historically, investigations into the sensory mechanisms of ...

Conversely, although CC OMVs induced less overall splenocyte proliferation, the absolute counts of lymphocytes, including NK cells, CD4+ T cells, CD8+ T cells, and NKT cells, were the highest (Figure ...

From the Department of Cardiology and Angiology I, University Heart Center Freiburg, Germany (D.W.) Faculty of Medicine, University of Freiburg, Germany (D.W.) K. Ley has received research funding for ...

Research Center for Environmental Quality Management, Graduate School of Engineering, Kyoto University, Otsu, Shiga 520-0811, Japan Key Laboratory of Industrial Ecology and Environmental Engineering ...

Interestingly, no alteration was seen in the myeloid compartment, except for a reduced infiltration of PMN-MDSCs, whereas a significant infiltration of NK and NKT cells could be observed in pairwise ...

and CD8 + T cells and no difference in the amount of NK and NKT cells in peripheral blood compared with age-matched reference values. • Longitudinal evaluation of immune cell counts in the same AT ...

CRISPR-based drug target discovery in cancer and autoimmunity A major part of the different projects in the lab involves using CRISPR-based custom screens as a discovery platform to understand complex ...

Figure 1. Signal transduction mechanism of EGFR (epidermal growth factor receptor) transactivation by angiotensin II (AngII) in vascular smooth muscle cells leading to vascular remodeling. Please note ...