In cancer-associated cachexia, elevated TNF-α and IL-6 exacerbate muscle and fat loss by regulating multiple metabolic signaling pathways, which could be ameliorated by Z526's suppression of NF-κB ...

Z526- a novel dithiocarbamate-like compound reverses cancer associated cachexia via mitigating NF-B signaling and oxidative ...

IL-6. The release of these inflammation-related factors triggers inflammatory responses, leading to processes like vasodilation, leukocyte infiltration, and tissue damage in inflammatory pathologies.

USD's anchor partnerships are primarily local, but also extend beyond the borders of our campus and nation. For many years, our faculty and students have engaged in meaningful work locally, whether it ...

In recent years, an important relationship between increased NF-κB activation and decreased PPAR-γ expression has been identified in the pathogenesis of systemic sclerosis (SSc). This imbalance has ...

Both transcriptomic analysis and network analysis revealed the JAK/STAT signaling pathway as a key mechanism. Ginsenoside Rh2 inhibited tumor growth in TNBC mice and reduced the expression of IL- 6, ...

HeLa cells express all core components of the NF-κB pathway and have a fully functional IL-1 system (Weiterer et al, 2020). They represent one of the most widely used cellular models to date (Adey et ...