now report that the deletion of two transcription factors linked to monocyte differentiation could confer limitless self-renewal capacity to mature differentiated macrophages. Surprisingly ...

More information: Alexandra Blanco et al, Monocyte to macrophage differentiation and changes in cellular redox homeostasis ...

For example, IL-4-based treatments could encourage differentiation of Ly6G + macrophages and subsequently boost progenitor cell proliferation and repair. “You have less control over that scenario, ...

we have investigated the developmental origin and homeostasis of macrophages and the related cell types monocytes and dendritic cells. These cells play a major role in diverse types of cancer and can ...