Recent studies have shed light on the role of Bone Marrow Stromal Cell-derived Exosomes (BMSC-Exos) in modulating the polarization of synovial macrophages. By inhibiting the PTEN induced putative ...

In obese individuals, macrophages enter a pro-inflammatory state known as M1 polarization, which contributes to chronic inflammation. This polarization promotes tissue damage, inflammation and ...

smu.edu.cn, baixc15{at}smu.edu.cn Objectives To investigate the roles and regulatory mechanisms of synovial macrophages and their polarisation in the development of osteoarthritis (OA). Methods ...

Dysregulation of macrophage polarization, in which pro-inflammatory M1 macrophage population fail to transition to an anti-inflammatory M2 macrophage phenotype, is a characteristic feature of poorly ...

Background The polarization of M1 macrophage facilitates steatotic liver graft injury and is regulated by metabolic reprogramming. We previously demonstrated that compromised PGC1α signaling mediated ...

3 Macrophages in the presence of interferon-γ and lipopolysaccharide (LPS), what is known as classical activation, acquire an inflammatory phenotype and are also termed M1 macrophages. On the other ...

Mechanistic studies showed that Lrrk2 promotes macrophage polarization toward the M1 phenotype by enhancing STAT1 phosphorylation in response to IFN-γ signaling. This function is dependent on the ...

This study aims to examine the role of SphK1 on hepatic macrophage recruitment and polarization in liver fibrosis. Conclusions Our findings demonstrated that SphK1 aggravated liver fibrosis by ...

To investigate whether Trib3 regulates the polarisation state of macrophages, bone marrow derived macrophages (BMDMs) were isolated and polarised in vitro to further characterise their pro- or anti- ...

while also mitigating bone marrow injury and increasing hematopoietic cells through mediating macrophage M1 differentiation, ...