当LPS进入宿主血液后，LBP与其紧密相连。其主要功能包括促使血液中LPS聚集体解离为单体，同时加速单体LPS与CD14的结合，如同脂质穿梭（shuttle）和呈递的使者，且具备催化功能。 LBP对游离的粗糙型LPS、光滑型LPS，以及革兰阴性细菌细胞膜上的LPS都展现出高度 ...

Furthermore, liver, but not whole-body, insulin resistance was detected in LPS-infused mice. CD14 mutant mice resisted most of the LPS and high-fat diet-induced features of metabolic diseases.

Results Individuals with wheat sensitivity had significantly increased serum levels of soluble CD14 and lipopolysaccharide (LPS)-binding protein, as well as antibody reactivity to bacterial LPS and ...

为解决 NACT 对乳腺癌患者外周单核细胞影响及预后贡献不明的问题，亚历山大大学研究人员开展相关研究。结果发现 NACT 影响 CD14+CD16 + 单核细胞和 sCD163 水平，且二者与临床反应有关。该研究为乳腺癌治疗提供新思路，值得一读。 埃及亚历山大大学医学研究所 ...

In response to LPS, both HC and AH monocytes express chemokines ... For these analyses, only monocytes were used (clusters labeled CD14_Monocyte1, CD14_Monocyte2, CD14_Monocyte3, and CD16_Monocyte).

Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a chronic, debilitating disease characterised by a wide range of symptoms that severely impact all aspects of life. Despite its ...

Macrophages are classically polarized into pro-inflammatory macrophages (M1) induced by LPS/ LPS plus IFN-γ or activated into anti-inflammatory macrophages ... and Itgax (CD11c), and another three ...

Objective Liver injury impacts hepatic inflammation in part via Toll-like receptor (TLR) signalling. Triggering receptor expressed on myeloid cells 2 (TREM-2) modulates TLR4-mediated inflammation in ...