Cell growth usually refers to cell proliferation, the increase in cell numbers that occurs through repeated cell division. Cell growth can also refer to the enlargement of cell volume, which can ...

Here the authors compare resting and IFN-α-treated islet β cells in vitro to find IFN-α inducing increased HLA-B expression, presentation of alternative epitopes, and activation of HLA-B ...

rendering the cells invisible to a patient’s immune system. A first-in-human study of Sana Biotechnology’s transplanted islet cells has shown potential as a possible treatment for type 1 diabetes, ...

Opens in a new tab or window Sana Biotechnology said a type 1 diabetes (T1D) patient received an allogeneic primary islet cell transplantation without immunosuppression. The company's engineered ...

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This study provides compelling evidence for functional subpopulations of β-cells responsible for Ca2+ signal initiation and maintenance using novel three-dimensional light sheet microscopy imaging and ...

Jin, Briggs and colleagues use light sheet imaging to reconstruct the islet three-dimensional Ca2+ network. The authors find that early/late responding (leader) cells are dynamic over time, and ...

8 note. The Seattle-based biotech is evaluating UP421, a donor-derived allogeneic primary islet cell therapy, as a type 1 diabetes treatment that doesn’t require the use of any immunosuppression.

In the same way that ChatGPT understands human language, a new AI model developed by computational biologists captures the language of cells to accurately predict their activities. In the same way ...

First-in-Human Study Provides Evidence that Sana’s Hypoimmune (HIP) Technology Enables Transplanted Islet Cells to Avoid Immune Rejection and Produce Insulin Without Immunosuppression Results ...

The study identified no safety issues, and the HIP-modified islet cells evaded immune responses. “These initial exciting results build upon the extensive preclinical and translational studies of Dr.