Here, in bone marrow transplantation and organoid culture models, T-cell-derived Interferon-γ is shown to promote STAT1-dependent intestinal stem cell c-MYC expression and epithelial regeneration.

Correspondence to Dr Sebastian Zeissig, Department of Medicine I, University Medical Center Dresden, and Center for Regenerative Therapies Dresden (CRTD), Technische Universität (TU) Dresden, 01307 ...

Histological analyses of the small intestine in C57BL/6 mice treated with 200[μg/ml NIC (which emulates active smoking) revealed that NIC exposure decreased villus length without affecting crypt size ...

The effects of signalling pathway modulators on the status of intestinal stem cell biology, crypt cell proliferation, migration, differentiation and shedding were determined. Results Native human ...

They showed that symbioses with bacteria have ... Microbial Cell Factories May Help Get to the Root of Understudied Plant Molecules Jan. 16, 2025 — A new tool could make it easier to study ...

Intestinal stem cell-specific TLR4 expression affects the proliferation and apoptosis rate in the intestinal crypt. In addition, stem cell lineage commitment is also influenced by stem cell ...

eLife is a non-profit organisation inspired by research funders and led by scientists. Our mission is to help scientists accelerate discovery by operating a platform for research communication that ...

Breast cancer, even after successful treatment, can sometimes remain a hidden threat, as certain cancer cells can lie dormant in the body for years before reactivating. This unsettling reality has ...

Nat Clin Pract Gastroenterol Hepatol. 2006;3(5):267-274.

Jan. 15, 2025 — While most known types of DNA damage are fixed by our cells' in-house DNA repair mechanisms, some forms of DNA damage evade repair and can persist for many years, new research shows.

crypt abscesses (accumulation of inflammatory cells within the crypts of the intestine), depletion of the mucin layer in the intestine, surface integrity, chronic inflammatory cell infiltration ...