Several things can trigger acid reflux or a GERD episode, including some eating habits (like having dinner very late at night) or eating certain foods (like spicy, acidic, or fatty foods).
Topical agents for melasma include phenols (hydroquinone), retinoids (tretinoin), alpha-hydroxy acids (glycolic acid), salicylic ... with prolonged use of high-concentration hydroquinone (Grimes ...