Researchers can experimentally interrogate the function of one or more genes using knockout or knockdown tools. Although both approaches ultimately interfere with gene function, knockout and knockdown ...
4 This technique, known as CRISPR-interference (CRISPRi) allows targeted ‘knockdown’, rather than knockout. “CRISPRi represses the gene of interest, instead of turning it off,” Donnelly ...
Both gene knockout and knock-in models are powerful tools widely used in biomedical research to gain important insights into ...
Most often, a technique called electroporation is used ... To produce a mouse that is homozygous for the target gene knockout, chimeric mice capable of passing the knockout mutation on to their ...
My laboratory studied the functions of neurotrophic factors in development and their relevance to neurodegenerative disease using a blend of transgenic mouse technology and anatomical, cell biological ...
Synthego, a leading genome engineering solutions company, today announced the launch of the Gene Knockout Kit v2. This is the only product that leverages a novel ...