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The main safety concern with mipomersen is increased hepatic TG accumulation and development of steatosis, which is due to decreased efflux of TG from liver. Increased hepatic TG by mipomersen is ...

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The American Cancer Society’s estimates for primary liver cancer and intrahepatic bile duct cancer in the United States for 2025 are: About 42,240 new cases (28,220 in men and 14,020 in women) will be ...

Dec. 13, 2024 — New research highlights the possibility of screening people with type 2 diabetes for liver damage at the same time as they undergo screening for eye ... Microbiome Changes in ...

Metabolic requirements of dividing hepatocytes are prerequisite for liver regeneration after injury. In contrast to transcriptional dynamics during liver repair, its metabolic dependencies remain ...

Three principal thyroid autoantigens are involved in AITD. These are thyroperoxidase (TPO), thyroglobulin (Tg) and the TSH receptor. Other autoantigens, such as the Sodium Iodide Symporter (NIS ...