This manuscript describes the identification and characterization of 12 specific phosphomimetic mutations in the recombinant full-length human tau protein that trigger tau to form fibrils. This ...
Scientists have long considered ketones (a fundamental chemical class) and esters (molecules formed when an acid reacts with an alcohol) to be locked treasure chests of possibilities.
It seeks to explain biological function in terms of molecular structure, dynamics and organization, from single molecules to supramolecular structures. Mutations in RAS and PI3Kα drive cancer by ...