We first analyzed the widely used Horvath clock, which was trained on data from several tissues and cell types to accurately predict age across the lifespan using methylation levels at 353 CpG sites.

DNA methylation is the covalent addition of methyl groups to DNA bases, typically the cytosine of CpG dinucleotides. It is catalyzed by methyltransferase enzymes using a S-adenosyl methionine ...

The methylation of plasma cell-free DNA (cfDNA) has emerged as a valuable diagnostic and prognostic biomarker in various cancers including colorectal cancer (CRC). Currently, there are no biomarkers ...

This method boasts a high degree of accuracy, even when working with CpG-rich regions. This robust combination of dPCR and MSRE offers rapid, cost-effective, and accurate methylation analysis.

Edited by: Eugene Russo A. Merlo, J.G. Herman, L. Mao, D.J. Lee, E. Gabrielson, P.C. Burger, S.B. Baylin, D. Sidransky, "5´ CpG island methylation is associated with ...

Predictive methylation signature for gemcitabine sensitivity in pancreatic ductal adenocarcinoma: A pathway to personalized treatment. This is an ASCO Meeting Abstract from the 2025 ASCO ...

Serum mucin 5AC (MUC5AC) as a predictor of outcomes and microscopic distant metastasis in pancreatic ductal adenocarcinoma (PDA). This is an ASCO Meeting Abstract from the 2025 ASCO Gastrointestinal ...

Dunn, recently carried out a study exploring how DNA methylation, an epigenetic modification that entails the addition of a methyl group to the DNA, contributes to the well-documented relationship ...

In a nutshell Scientists discovered that random DNA mutations don’t just cause local damage, they trigger widespread changes ...

Introduction: DNA methylation inhibitors have been approved for the prevention of Acute Myeloid Leukemia (AML), and their safety profile is not fully characterized. This study was aimed at evaluating ...

The tenuous link between cancer and epigenetic changes, changes in gene expression without DNA mutations, has been strengthened by Joe Costello, assistant professor at the University of California, ...