We first analyzed the widely used Horvath clock, which was trained on data from several tissues and cell types to accurately predict age across the lifespan using methylation levels at 353 CpG sites.

The methylation of plasma cell-free DNA (cfDNA) has emerged as a valuable diagnostic and prognostic biomarker in various cancers including colorectal cancer (CRC). Currently, there are no biomarkers ...

Here, the authors predict DNA methylation at CpG sites for seven cancer types and investigate how these influence cancer risk. DNA methylation from cell-free DNA (cfDNA) can be profiled using ...

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该研究从全基因组视角揭示了男性长寿人群存在大量特异 DNA 甲基化修饰且与肿瘤等重大老年疾病相关。这为男性长寿老人数量较少但健康状况更佳提供了科学解释，为剖析男性特异的健康老化分子调控机制提供了新证据。