Of interest is the delineation of two macrophage subtypes: Anti-mac cells (CD45+CD11b+CD86+) and Pro-mac cells (CD45+CD11b+ARG+), with the proportion of Pro-mac/pro-tumorigenic cells significantly ...

Background The immune suppression mechanisms in pancreatic ductal adenocarcinoma (PDAC) remain unknown, but preclinical ...

Metastasis is a multistage process that requires cancer cells to escape from the primary tumour, survive in the circulation, seed at distant sites and grow. Each of these processes involves rate ...

Statistical analysis was performed using GraphPad Prism 9.0 (GraphPad Software, CA). SAR441566 potently inhibits zymosan-activated CD11b expression on granulocytes in human whole blood The potency of ...

It is evident from the data presented in this Review that primary tumours and their metastatic off-shoots are complex ecologies consisting of numerous cell types. Many of these are derived from ...

Correspondence to Dr Ulrike Baschant; Ulrike.Baschant{at}uniklinikum-dresden.de and Professor Jan P Tuckermann, Institute for Comparative Molecular Endocrinology, University of Ulm, Ulm 89081, Germany ...

The three-signal paradigm tries to capture how the innate immune system instructs adaptive immune responses in three well-defined actions: (1) presentation of antigenic peptides in the context of MHC ...