and the identification of these catalytic residues provides a critical piece of the puzzle, enhancing our understanding of how these enzymes facilitate the complex modifications essential to ...

The data strongly suggest that the Rpn5 subunit is centrally positioned, thereby allowing for interaction with the catalytic and base subunits and with the hinge region of the complex. In ...

The Post group has worked to understand the basis of the catalytic power of enzymes using information from crystallography, kinetics, and a description of conformational distributions from molecular ...

This illustration depicts the process of enzyme catalysis. The enzyme (blue) binds to its substrate (red) to form an enzyme-substrate complex. The enzyme then catalyzes the conversion of the substrate ...

Enzymes, natural catalysts ... supports a Hoveyda-Grubbs ruthenium complex, called a precatalyst, which initiates the catalytic process by reacting with the substrate. The designed nanosystem ...

Another related area of interest is to explore how enzymes may have evolved directed motions that are correlated to the reaction coordinate and are essential for their full catalytic power ... of a ...

Biosynthetic pathways requiring nitrogen use "complex" enzymes known as glutamine amidotransferases (GATs) to remove nitrogen from the carrier molecule glutamine. Our work has elucidated the ...

These enzymes require NAD (nicotinamide adenine dinucleotide) as a cofactor, which is consumed by the catalytic reaction ... in principle feasible and make complex, multi-step reactions ...