State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China University of Chinese Academy of Sciences, Beijing 100049, China State Key ...

The team evaluated more than 4,000 clones before identifying an enzyme S N Ar1.3 that contains six mutations and is 160-fold more active than the parent enzyme.

The engineered enzymes had similar gene-editing efficiency and reduced immune responses compared to standard nucleases in mice. Appearing today in Nature Communications, the findings could help ...

The gene snbU encoding a predicted cytochrome P450 monooxygenase has been demonstrated to be involved in the biosynthesis ... FH carried out the EMSA assays and pristinamycin production analysis. AK ...

Department of Biochemistry and Biophysics, Texas A&M University, 301 Old Main Drive, College Station, Texas 77845, United States ...

5-hydroxyomeprazole is then transformed into 5-hydroxyomeprazole sulfone by CYP3A4. Omeprazole is metabolized ... rapid metabolizers (with an increased enzyme activity), intermediate metabolizers ...

The application of pharmacogenetics in identifying single nucleotide polymorphisms (SNPs) in DNA sequences that cause clinically significant alterations in drug-metabolizing enzyme activities is ...

In summary, the genetic polymorphism of CYP2D6 and co-administration of CYP2D6 inhibitors may have less impact on the risk of acute toxicity than previously thought, whereas the role of metabolism by ...