smu.edu.cn, baixc15{at}smu.edu.cn Objectives To investigate the roles and regulatory mechanisms of synovial macrophages and their polarisation in the development of osteoarthritis (OA). Methods ...

The underlying regulatory mechanisms of metabolic switching are assessed by both in vitro and in vivo studies. Conclusions Selectively modulating the ‘context’ of glycolytic macrophages in HCC tumours ...

肝脏巨噬细胞在调节肝细胞代谢和维持肝脏免疫耐受方面发挥核心作用。正常生理条件下，肝脏巨噬细胞倾向于 M2 表型，可通过分泌白细胞介素（IL）-4 和 IL-13 抑制炎症。然而，在 NAFLD 进展时，肝星状细胞激活、血液中脂多糖水平升高以及 FFA 激活炎症小体等变化，会刺激炎症发生，增加分泌促炎细胞因子的 M1 巨噬细胞比例。