A recent study published in eLife offers a new perspective on the development of Alzheimer’s disease, suggesting that the ...

In addition to the formation of senile plaques and neurofibrillary tangles in brain, the pathological hallmarks of Alzheimer disease (AD), there is substantial neuronal and synaptic loss in the ...

During her talk, Rice had described how a peptide called amyloid precursor protein (APP) gets broken down in the brain into smaller pieces such as amyloid-β, the peptide that notoriously goes on to ...

A man who should have developed early-onset Alzheimer's disease due to a genetic mutation is still symptom-free in his 70s.

Scientists have identified a biomarker for Alzheimer's that may help doctors spot the early signs of protein buildup in the ...

Researchers at Washington University School of Medicine in St. Louis have conducted a longitudinal study on an individual ...

Here we demonstrate that a modest increase in astroglial TGF-β1 production in aged transgenic mice expressing the human β-amyloid precursor protein (hAPP) results in a three-fold reduction in ...

A groundbreaking study reveals how a rare combination of genetics, proteomics, and environmental factors may hold the key to ...

In this study, we have developed and characterized a novel human retinal organoid (RO) model derived from induced pluripotent stem cells (iPSCs) from patients with familial AD due to mutations in the ...