UGent.be Objectives A20 is an important endogenous regulator of inflammation. Single nucleotide polymorphisms in A20 have been associated with various immune-mediated inflammatory diseases, and ...

or TNFα - which as its name implies can cause cancer cells to self-destruct - is manipulated by cancer to instead aid its survival. "Here we show that TNFα supports aggressive breast cancer by first ...

Inflammatory cytokine secretion and Nod2-mediated NF-κB activation were analysed using the transfected cells. Conclusions A C243Y mutation in A20/TNFAIP3 was likely responsible for increased ...