Despite being an RNA polymerase II transcript, the 3’ end of MALAT1 is produced not by canonical cleavage/polyadenylation but instead by recognition and cleavage of the tRNA-like structure by RNase P ...

tRNAs have a distinct cloverleaf secondary structure and an L-shaped tertiary structure. The cloverleaf structure is formed by the folding of the single-stranded tRNA molecule, which is typically ...

The opposite end of the folded structure, which is the 3' end of the tRNA, binds to its corresponding amino acid at an attachment site that is also three nucleotides long, invariably CCA.

much like a spotlight. We use these shadows to compute the shape and structure of the protein. We used this technique to ...