Tau is a protein that builds up and moves between nerve cells in the brains of people living with Alzheimer’s disease, causing damage. Professor Mudher is using clever genetic manipulation in fruit ...

They consist of aggregates of abnormally phosphorylated tau proteins that are altered in conformation. Conformational changes in tau proteins are thought to be the earliest neurobiological changes ...

Scientists have developed two new imaging agents that work better than the only currently approved one for detecting tau ...

A study by researchers at Baylor College of Medicine and the Jan and Dan Duncan Neurological Research Institute (Duncan NRI) ...

Working with human cells and animal models of tau-driven dementia, the researchers are the first to show that TYK2's modifications to tau contribute to tau-mediated disease. "We found that TYK2 ...

Tau is a microtubule-associated protein encoded by the MAPT gene located on chromosome 17q21. It promotes microtubule assembly and stability and may play a role in establishing and maintaining ...

Tau is a microtubule-associated protein that helps to stabilize the structure of neurons, specifically by supporting ...

A comprehensive study of brain scans from more than 600 people has shed new light on the relationship between tau protein and ...

Researchers from South Korea and the United States have found a new method to eliminate the tau protein, which is known to cause Alzheimer’s disease. The research team led by Lee Jeong-soo ...

Tau proteins with cysteine groups bearing thiol groups (S) undergo chemical changes under oxidative stress to form disulfide bonds, making a toxic mutant of the tau protein that can aggregate.

This manuscript describes the identification and characterization of 12 specific phosphomimetic mutations in the recombinant full-length human tau protein that trigger tau to form fibrils. This ...