Our ultimate goal is to define if manipulating the cytoskeleton of cancer cells will lead to improved efficacy of therapeutic approaches in patients with metastatic disease, with a special focus on ...

Our laboratory is focusing on identification of metastasis and tumor cell invasion-associated molecules, by using advanced molecular biology and the phage display technology. We are also developing ...

An enzyme called MICAL2 promotes tumor growth and metastasis in the most common form of pancreatic cancer, according to a new study. Pancreatic cancer kills 50,000 people each year, according to ...

Cancer metastasis -- the spread of cancer to other organs -- is the leading cause of death among cancer patients. Researchers have now uncovered a 'genetic signature' of 177 genes shared across ...

Metastasis causes >90% of cancer death. The emergence, persistence, therapy resistance and lethality of metastatic cancer is driven by dynamic and tenacious metastasis stem cells (MetScs). The Ganesh ...

Back to Finland she founded her own research group of Translational Cancer Biology in the Research Program Unit of the Faculty of Medicine, University of Helsinki, Finland. She currently leads key ...

These processes can also be coopted to promote the renegade cell movements that lead to tumor cell metastasis. We are using molecular ... How does this asymmetry mobilize the cytoskeleton to promote ...

Recent work from our lab and others have localized the chromatin modifiers lost in RCC at the mitotic spindle. This unique convergence of RCC tumor suppressors on the cytoskeleton evokes questions ...

The arrow between the two states indicates that the synergistic binding of Cdc42, cytoskeleton proteins (called downstream effectors of IRSp53 and includes the tumor-promoting factor Eps8 ...