Based on early studies, it was hypothesized that expression of Fas ligand (FasL) by tumor cells enabled them to counterattack the immune system, and that transplant rejection could be prevented by ...

However, as tumors evolve, they exploit the TIME to ... thereby influencing processes like immune escape, angiogenesis, and metastasis. HCC is particularly adept at manipulating the TIME via ...

Immunotherapy is based on harnessing a person's own immune system to attack cancer cells. However, patients with certain tumors do not respond to these therapies and it remains unclear why.

Immunotherapy, cancer treatments that alter the immune system, making it better apt to fight tumor cells, have provided novel ...

Many of the cells in the innate immune system produce cytokines or interact with other cells directly to activate the adaptive immune system. In cancer cells, mutations can lead to expression of tumor ...

Cancer is a multifactorial disease that affects millions of individuals worldwide and has a profound impact on public health. The heterogeneity of solid ...

These platforms are leading to a better understanding of how tumor cells interact with each other and with their microenvironment, how they escape treatment and the immune system. We are using this ...

Immunotherapy is a treatment that strengthens the ability of the patient’s own immune system to detect and destroy cancer. Cancer cells often have mutations that allow them to escape the immune system ...

Much of our knowledge of the protein PD-1, a leading cancer treatment target, comes from studies in mice. In a comprehensive assessment of PD-1, researchers have found that PD-1 in mice is ...