This reduces T-cell activation and cytokine production, as well as encouraging Treg cell recruitment to the fetal–maternal interface. These changes are critical in promoting maternal tolerance.

This challenge has focused researchers on understanding Tregs' tumor-specific mechanisms to selectively target Tregs within ...

As they continue their work, Ferreira and his team are continuing to investigate how a CAR affects a Treg's work. "We're trying to understand the mechanism of the intrinsic signaling [changes ...

Coya Therapeutics advances COYA 303 for inflammatory diseases, combining COYA 301 and GLP-1 RA for a synergistic anti-inflammatory effect.

Potential immune mechanisms are: downmodulation of cytokine ... Transmembrane TNF-α; Treg: T regulatory cell.

Coya Therapeutics (COYA) announced the expansion of its investigational pipeline and advancement of COYA 303 for the treatment of inflammatory ...

However, the exact molecular mechanisms and processes that are ... they have a considerable influence on the differentiation of regulatory T cells (Treg cells), which in turn prevent an overactive ...

We found that TAMs can be dietarily and genetically reprogrammed to engage the evolutionarily ancient cell quality control mechanism–cell competition ... tumor growth induces overly activated ...