The results highlight an important physiological function of PGAM in the differentiation and suppressive activity of Treg cells by regulating serine synthesis. This role is proposed to intersect with ...

cell communication and transcriptional regulation, consistent with the expected role of Foxp3 in Treg differentiation. Thus, the role of Foxp3 as a forkhead nuclear transcription factor regulating ...

Specifically, Breg suppresses T helper (Th) 1/17 cells differentiation and their capacity to release inflammatory cytokines (i.e., IFN-γ and TNF-α) (48, 50); Breg also enhances the activity of Treg ...

Immune cells called regulatory T cells have long been known for their role in countering inflammation. In the setting of ...

The differentiation of CD4 T cells into T helper 1 (TH1) or T follicular helper (TFH) subsets is often critical for controlling tumors, while their transformation into regulatory T cells (Tregs ...

Objectives The study is to evaluate the characteristics and differentiation mechanisms of Th1-like Treg cells in SLE patients and the role of TIGIT in regulating immunosuppressive function. Results ...

Examples of possible clinical therapy include administration of regulatory T cells in preventing autoimmune attacks ... with the eventual goal of a comprehensive research project in T cell ...

VD inhibits of Th1 cell differentiation and the production of Th1-specific cytokines. VD facilitates Treg cell generation and activity. VD has a role in the prevention of autoimmune diseases such ...

Objectives The tuning effects of JAK/TYK2 inhibitors on the imbalance between T follicular helper (Tfh) and T regulatory (Treg) cells, related to systemic lupus erythematosus (SLE) pathogenesis, were ...