They consist of aggregates of abnormally phosphorylated tau proteins that are altered in conformation. Conformational changes in tau proteins are thought to be the earliest neurobiological changes ...
This manuscript describes the identification and characterization of 12 specific phosphomimetic mutations in the recombinant full-length human tau protein that trigger tau to form fibrils. This ...
A hallmark of Alzheimer’s disease (AD) is the deposit of phosphorylated tau proteins that form neurofibrillary tangles inside neurons. While they’re known biomarkers of AD, researchers still ...
The current human tissue-based study provides convincing evidence correlating hippocampal expressions of RNA guanine-rich G-quadruplexes with aging and with Alzheimer's Disease presence and severity.
Tau protein is a microtubule-associated protein (MAP) known to stabilize the internal structure of neurons, binding to microtubules. These are microscopic tubular structures that support the ...
The oral herpes virus appears to be linked with Alzheimer’s disease, suggesting that the common infection might play a role in the disease, a new study published in the journal Cell Reports says.