Prolonged illnesses like cancer and chronic infections often leave the immune system in a state of exhaustion, where its ...

The malfunctioning mitochondria seem to poison the immune cells, explains Yosuke Togashi, a pulmonary physician and ...

More information: David S. Iu et al, Transcriptional reprogramming primes CD8+ T cells toward exhaustion in Myalgic encephalomyelitis/chronic fatigue syndrome, Proceedings of the National Academy ...

T-cells from the liver and lymph nodes show promising potential for future treatments of liver cancer, according to a new ...

Researchers found that bioengineered CAR-T cells when mixed with other immune cells can "donate" proteins, suggesting ...

Findings indicate that altering glucose metabolism in T cells boosts their therapeutic potential against melanoma, paving the way for improved immunotherapies.

While naïve T cells lacked the disease-fighting imprinting of memory cells, they became more effective when RUNX2 was added. They also lived longer and the gene protected them against exhaustion ...

Penn Medicine is one of the first institutions to develop FDA-approved CAR T-cell therapies. This therapy is currently ...