The IR bound IRS-1 is then itself tyrosine phosphorylated, creating a binding site for the SH2 domain of the adapter protein Grb2. The two SH3 domains of Grb2 bind proline rich motifs in the C ...

These phosphotyrosine interaction domains have three distinct biological roles: (i) recruiting SH2 or PTB domain-containing proteins to tyrosine-phosphorylated and activated receptor tyrosine ...