Drugs targeting amyloid plaques have failed to show efficacy in clinical trials. A new approach is needed to tackle AD ...

The aggregation of tau, leading to the formation of neurofibrillary tangles (NFTs), is likely to be associated with toxic gains-of-function. For example, NFTs may contribute to disease progression ...

The possibility that Alzheimer’s disease diagnosis is associated with viruses, bacteria, fungi, and parasites has been ...

Despite decades of starts and stops, new treatments and key genetic discoveries are giving researchers great hope for slowing or eventually preventing Alzheimer’s disease.

Another protein, hyperphosphorylated tau (pTau), also accumulates as toxic neurofibrillary tangles. Together, amyloid-β plaques and pTau tangles result in brain damage, neuroinflammation and ...

In conditions like Alzheimer's and frontotemporal dementia, tau proteins become damaged, detach, and form toxic neurofibrillary tangles that harm neurons. This damage disrupts communication in the ...