Determining the exact cause of the behavioural abnormalities, which may result from the motor deficits, will require extended analysis; however, the severe neurofibrillary pathology in the basal ...

The tissue abnormalities first defined by Alzheimer as clumps and tangles among neurons in the cortex are more specifically defined as amyloid plaques and neurofibrillary tangles. Plaques are ...

Alzheimer's disease is a multifactorial neurodegenerative disorder, characterized by amyloid plaques, neurofibrillary tangles, and gliosis. Beyond genetic and age-related factors, diverse risk ...

Another protein, hyperphosphorylated tau (pTau), also accumulates as toxic neurofibrillary tangles. Together, amyloid-β plaques and pTau tangles result in brain damage, neuroinflammation and ...

Another protein, hyperphosphorylated tau (pTau), also accumulates as toxic neurofibrillary tangles. Together, amyloid-β plaques and pTau tangles result in brain damage, neuroinflammation and ...

It is pathologically characterized by the deposition of amyloid-β (Aβ) and the development of neurofibrillary tangles in the brain. Over time, an increased accumulation of these proteins leads ...