Three of these six pathogens are antibiotic-resistant Gram-negative bacteria. Recently, antibacterial drugs against ESBL-producing Gram-negative bacteria accounted for ∼15% (2 out of 13 ...

A new antibiotic against gram-negative bacteria hasn’t been developed since the 1970s. Now, a European research team led by Swedish scientists has discovered multi-drug-resistant bug-killing ...

The emergence of resistant to carbapenems Gram-negative bacteria (CR GNB) has severely challenged antimicrobial therapy. Many CR GNB isolates are only susceptible to polymyxins; however ...

Antimicrobial resistance (AMR) has emerged as one of the leading public health threats globally, including South Africa ...

Most resistant to carbapenems Gram-negative bacteria isolates are only susceptible to polymyxins, which are commonly the main antibiotic class used against these isolates. Some shortcomings of ...

How can we prevent antibiotics from becoming obsolete? All that said, when it comes to antibiotic resistance, gram-negative bacteria have an edge thanks to their double membranes. The outer ...

The compound, called LPC-233, is a small molecule that has proven effective at wrecking the outer membrane lipid biosynthesis in every gram-negative bacterium it was tested against. Co-authors at the ...

Dr. Haldar will describe his work towards designing multi-target acting next-generation analogues which possess additional modes of action and have demonstrated superior efficacy in tackling ...