The relationship between DNA methylation and gene expression is driven by sequence variants, according to a recent study conducted by researchers at deCODE Genetics, an Amgen subsidiary.
“Generally, methylation at the promoters of genes is associated with a packed down ... It's not like an on- or off-switch, it’s not necessarily driven by a point mutation. It's driven by [gene ...
The example presented here highlights the use of a multiplex dPCR assay in examining the methylation status of an RASSF1A promoter—a tumor suppressor gene whose dysregulated expression has been ...
Recent research gathered evidence suggesting that DNA methylation can serve as a "dimmer switch" that turns gene expression up or down. Yet most past studies have focused on its contribution to ...
The methylation of plasma cell-free DNA (cfDNA) has emerged as a valuable diagnostic and prognostic biomarker in various cancers including colorectal cancer (CRC). Currently, there are no biomarkers ...
This is a useful study that seeks to address the role of the TET family of DNA demethylation enzymes in pancreatic beta cell senescence in the context of type 2 diabetes (T2DM). Although the concepts ...