According to a meta-analysis from the United States, obesity is associated with 24-33% of all kidney diseases (2). Macrophages are divided into two types: the pro-inflammatory M1 and the ...

Dysregulation of macrophage polarization, in which pro-inflammatory M1 macrophage population fail to transition to an anti-inflammatory M2 macrophage phenotype, is a characteristic feature of poorly ...

Recent studies suggest that these effects are partly mediated through the regulation of macrophage polarization, wherein macrophages differentiate into pro-inflammatory M1 or anti-inflammatory M2 ...

smu.edu.cn, baixc15{at}smu.edu.cn Objectives To investigate the roles and regulatory mechanisms of synovial macrophages and their polarisation in the development of osteoarthritis (OA). Methods ...

Background Macrophage lineage may undergo two different polarization states: classically activated (M1) and alternatively activated (M2) macrophages: both macrophage populations represent the extremes ...

Researchers focused particularly on the role of M1 and M2 macrophages in the tumor microenvironment. Macrophages are immune ...

This study aims to examine the role of SphK1 on hepatic macrophage recruitment and polarization in liver fibrosis. Conclusions Our findings demonstrated that SphK1 aggravated liver fibrosis by ...

Mechanistic studies showed that Lrrk2 promotes macrophage polarization toward the M1 phenotype by enhancing STAT1 phosphorylation in response to IFN-γ signaling. This function is dependent on the ...

Objective Monocyte chemotactic protein-1-induced protein 1 (MCPIP1) is highly expressed in inflamed mucosa of inflammatory bowel disease (IBD) and negatively regulates immune response, while the ...