"Comprehensive genomic analyses of tumor DNA indicate that they originate from liver cells damaged by MASH, emphasizing a direct link between diet-induced DNA damage and the development of cancer ...
However, prolonged metabolic stress allows once-senescent liver cells to start dividing and progress to cancer. A MASH-inducing diet caused DNA damage in the liver cells (hepatocytes) of MUP-uPA mice.
Glycolysis is an important sugar degradation pathway that cancer cells in particular depend on. Scientists at the German Cancer Research Center (DKFZ) have now shown that liver cancer cells in mice ...