Our livers contain many different types of immune cells. New research by the team of Prof. Charlotte Scott (VIB-UGent Center ...

However, it wasn't the typical liver cells that responded, but a type of immune cell called Kupffer cells that are known for ...

Research from VIB-UGent identifies lipid-associated macrophages and LAM-like Kupffer cells as critical for liver repair. The ...

Objectives Kupffer cells (KCs) play a key role in maintaining liver homeostasis, hepatotoxicity and in liver pathology, but their functional status cannot be directly assessed in vivo (1-5). We report ...

In the healthy liver, most macrophages are classified as Kupffer cells (KCs). However, upon liver injury, as seen, for example, in obesity, another subset of macrophages called lipid-associated ...

Interleukin 18 (IL-18), which is a recently cloned cytokine synthesised by Kupffer cells, has been shown to activate macrophages.1 Macrophages and T cells have been reported to be activated in ...

Canada Excellence Research Chair in Immunophysiology and Immunotherapy Paul Kubes reflects on progress in research, building a team, and his vision for the future of immunology after his first year at ...

In 1876, Karl Wilhelm von Kupffer identified what he believed to be a single type of star-shaped cell in liver tissue. Now, immunologist Martin Guilliams from Ghent University and the VIB ...

It was used in that paper to predict ligand-receptor pairs specific for the Kupffer cell niche in mouse and human. For users interested in applying Differential NicheNet to their own data, we ...