The researchers found that heterozygous mice (those with a moderate number of mutated mitochondria) seemed to amplify leukemia growth. Homozygous mice with a high number of mutations had the ...

EAE was induced with myelin oligodendrocyte (MOG 35-55) peptide in Scn8a dmu/+ mice, which have reduced Nav1.6 levels. Scn8a dmu/+ mice demonstrated improved motor capacity during the recovery and ...

These ES cells are heterozygous for the knockout mutation. Although these cells will grow and divide in culture, they cannot form an embryo that will develop into a mouse on their own. Step 4 ...

Hemann et al. crossbred telomerase-deficient mice having short telomeres with mice heterozygous for telomerase activity that have long telomeres. They found that the phenotype of the telomerase null ...

smmu.edu.cn, zhsli{at}81890.net Recent publication of Hegyi and Sahin-Tóth reported that CPA1 p.n256K mutant mice developed chronic pancreatitis (CP) through endoplasmic reticulum stress.1 This, along ...

Methods We developed a knock-in mouse harbouring a heterozygous (±) human disease causing mutation in BMPR-II: a nonsense mutation in the cytoplasmic tail (R899X) to determine the in vivo physiologic ...

with a homozygous floxed mouse (B). The offspring are heterozygous for the floxed target gene (C) and breed with the homozygous floxed mouse (B). The resulting experimental mouse is hemizygous for Cre ...