Fatty liver disease, the excessive lipid accumulation in the liver, is a frequent metabolic condition that can progress in cancer. Despite years of research, targeted treatments are still lacking and ...

The transcription factor sex-determining region Y-related high-mobility group-box gene 9 (SOX9) plays a critical role in ...

The endogenous pathway involves the liver synthesizing lipoproteins. TG and cholesterol ester are generated by the liver and packaged into VLDL particles and then released into the circulation.

More information: Preethi Chandrasekaran et al, The Role of SCAP/SREBP as Central Regulators of Lipid Metabolism in Hepatic Steatosis, International Journal of Molecular Sciences (2024). DOI: 10. ...

Peptidomics offered new diagnostic insights into the underlying processes of metabolic dyfunction-associated steatotic liver ...

There are many drugs that target lipid metabolism in other body systems, such as in the liver, so we might be able to change this system quite dramatically using tools we already have." ...

The Farese & Walther laboratory investigates cellular lipid and energy metabolism, in particular the mechanisms and physiology of neutral lipid synthesis and storage in lipid droplets. More broadly ...

Patients with metabolic dysfunction-associated steotohepatitis (MASH) who are already taking a glucagon-like peptide-1 ...