Early versions of these drugs caused drowsiness, so drug companies spent years trying to design more specific H1 antagonists to avoid this side effect. They finally succeeded in the late 1980s ...

The biosimilar's safety and immunogenicity profiles were found to be comparable to those of the reference product in the ...

For the antihistamine desloratadine, in vitro studies have revealed it to be a highly potent H 1-receptor antagonist and inhibitor of inflammatory mediators. Animal models with desloratadine have ...