7 Humanized Mouse Models of Genetic Disorders Researchers use humanized mice to develop precision medicine for genetic disorders, which must be preclinically tested in relevant cell and animal models.

In the new study, mice were created through genetic editing of mouse embryonic stem cells targeting a class of mammal-specific genes known as imprinted genes, of which there are about 200 ...

the UK Dementia Research Institute at University College London and other institutes recently introduced new genetically modified mouse models that express humanized versions of MAPT, a gene known ...

Scientists have discovered a potential new treatment for familial hypercholesterolemia, inspired by signs seen in the Mona ...

Because humanized FcRn mice express only hFcRn, they can be used to more reliably assess the therapeutic efficacy of candidate hIgG mAbs. • Each FcRn strain has a C57BL/6J genetic background ...

In the new study, mice were created through genetic editing of mouse embryonic stem cells targeting a class of mammal-specific genes known as imprinted genes, of which there are about 200 ...

When I received my genetic test report in 2011, the world had never heard of base editing. It's a huge privilege to have the opportunity to point these powerful new tools at our disease." ...

Researchers at the Broad Institute of MIT and Harvard have developed a gene-editing treatment for prion disease that extends lifespan by about 50% in a mouse ... of the genetic mutation causing ...