FGF receptors (FGFRs ... FGF19 subfamily holds the greatest promise for therapeutic development. These ligands circulate throughout the body owing to weak affinity for HSGAG (heparan sulphate ...
Fgf ligands are normally expressed in the primordium leading zone; however, they were expressed throughout apc mutant primordia, showing that Wnt–β-catenin signalling induces Fgf ligand expression.
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