Medications called estrogen blockers are among the treatment options for those with low testosterone and higher estrogen. This article discusses how estrogen functions in males and symptoms of a ...

Aromatase inhibitors work by powerfully blocking the conversion of androgen precursors into estrogens, which lowers estradiol levels in the bloodstream and estrogen levels in peripheral tissues.

Unlike these therapies, our strategy uses novel 17-β-hydroxysteroid dehydrogenase (HSD17B) inhibitors which act locally, without impacting the systemic estrogen level,” said company CEO Risto ...

Overall, the ongoing research into 17β-HSDs emphasizes their significance in managing estrogen-dependent diseases. By developing selective inhibitors, researchers aim to create targeted therapies ...

Cognitive dysfunction has been considered as a morbid condition that may possibly result from aromatase inhibitor therapy, the standard treatment in postmenopausal, estrogen/progesterone receptor ...

Maintaining treatment with CDK4/6 inhibitors significantly suppresses the growth of breast cancer cells, even after drug resistance has developed, according to new research.

Paolo Tarantino, MD, PhD, discusses the approval of the oral therapy elacestrant for patients with estrogen receptor-positive, HER2-negative advanced or metastatic breast cancer with ESR1 mutations.

The Fuqua laboratory has determined that the K303R mutation alters many aspects of hormone action, including binding to co-regulatory proteins, enhanced stability, estrogen hypersensitivity, response ...