The successful and safe delivery of therapeutics relies on understanding how easily drugs can pass through biological ...

with a focus on the impact of chemical and physical properties on drug solubility and permeability. The likelihood of drug interactions increases for highly soluble drugs, manifesting through ...

New research has outlined guidance for using AI to help bridge the gap between in silico, in vivo and in vitro drug testing.

Passive diffusion and transporters coexist to affect drug disposition. Join Research Fellow Li Di of Pfizer during this free interactive broadcast as she discusses why design principles that increase ...

Applications of the concept of drug-likeness, which involve consideration ... candidates owing to issues such as poor solubility and permeability. Seeking to understand why, Christopher Lipinski ...

Welcome to our repository, here we provide machine learning model to efficiently predict the blood-brain barrier (BBB) permeability of target drug compounds in early stage drug discovery process. BBB ...

Division of Applied Regulatory Science, Office of Clinical Pharmacology, Office of Translational Sciences, Center for Drug Evaluation and Research, United States Food and Drug Administration (FDA), ...

Understanding how bacteria control the entry and efflux of chemicals helps us to explain and possibly reverse antimicrobial drug resistance. Even when antimicrobials gain access ... The combination of ...