perhaps by blocking the promoters at which activating transcription factors should bind. Presently, the exact role of methylation in gene expression is unknown, but it appears that proper DNA ...

Andrew Teschendorff, Professor at the Chinese Academy of Sciences, is developing computational systems-biological tools to ...

Transcription is the process by which an ... Here, the authors show that loss of DNA methylation during development allows Cdx2 to activate target genes. Riboswitches are RNA sensors that allow ...

The methylation of plasma cell-free DNA (cfDNA) has emerged as a valuable diagnostic and prognostic biomarker in various cancers including colorectal cancer (CRC). Currently, there are no biomarkers ...

Sen and her colleagues studied fragments containing cryptic sites and compared the levels of histone methylation, which winds up DNA and switches it “off” by making it unavailable for transcription, ...

In NSC lineage progression, genes with increased methylation downstream of the transcription start site (TSS) showed reduced ...

“Today, when we don’t know what causes a disease, we say it’s likely epigenetic. In a sense, I think this epigenetic viewpoint is right, but we need much more evidence to get a defined picture.” Cedar ...

DNA damage is a natural occurrence ... solid tumors and has also been identified as a transcription repressor. The role of this EZH2- mediated methylation is two-fold, the scientists discovered.

and methylation. One of the most important properties of guanine is its ability to form three hydrogen bonds with cytosine. This strong base pairing is crucial for the stability of the DNA double ...

The Epigenetics Research Innovation Lab (ERIL) has been established to contribute to the growing epigenetics research community at MSK and support efforts to define the epigenetic mechanisms that ...