Chloroquine appears to inhibit in vitro SARS virus' replication and to interfere with SARS-CoV2 receptor (ACE2). Chloroquine and hydroxychloroquine impede lysosomal activity and autophagy, leading to ...

Again, these results were confirmed by inhibiting autophagy with RNA interference instead of chloroquine. Additional treatment with chloroquine had no further benefit in this setting. This study ...

In chloroquine induced autophagy the surface charge of the outer plasma membrane changes which F2N12S can measure by alterations in the intensity of the two emissions, which emit more at 530nm (green) ...

Results EoE-relevant inflammatory conditions promoted autophagy and basal cell hyperplasia in three independent murine EoE models and oesophageal organoids. Inhibition of autophagic flux via ...

This study aims to observe the effect of autophagy and how it alters the gut microbiota on colitis mice. Methods Twenty-four Balb/c mice aged 6–8 weeks were randomly divided into four groups, and ...

Autophagy was targeted by conditional inactivation of autophagy-related gene 7 (Atg7) and by treatment with chloroquine (CQ). Bone density was evaluated by microCT. The role of autophagy on ...

This study presents a valuable finding on the alterations in the autophagic-lysosomal pathway in a Huntington's disease model. The evidence supporting the claims of the authors is solid. However, the ...

In general, this is not an early event in autophagy and the the role of PS externalization is unclear in autophagy ... as a marker for autophagosomes and hence the detection of autophagic cells. The ...

Methods PMA-transformed and LPS-stimulated U937 macrophages were treated with three autophagy-modifying reagents—3MA, chloroquine, and rapamycin. The expression of three IL-1 family cytokines (IL-37, ...