The Post group has worked to understand the basis of the catalytic power of enzymes using information from crystallography, kinetics, and a description of conformational distributions from molecular ...

This illustration depicts the process of enzyme catalysis. The enzyme (blue) binds to its substrate (red) to form an enzyme-substrate complex. The enzyme then catalyzes the conversion of the substrate ...

and the identification of these catalytic residues provides a critical piece of the puzzle, enhancing our understanding of how these enzymes facilitate the complex modifications essential to ...

Millions of individuals rely on effective medications to manage diseases like cancer and diabetes. For those with chronic myeloid leukemia (CML), advancements in treatment selection could ...

Another related area of interest is to explore how enzymes may have evolved directed motions that are correlated to the reaction coordinate and are essential for their full catalytic power to be ...

These enzymes require NAD (nicotinamide adenine dinucleotide) as a cofactor, which is consumed by the catalytic reaction ... in principle feasible and make complex, multi-step reactions ...